188 papers
Developmental biology explores the incredible journey of how a single cell transforms into a complex, living organism. This field investigates the molecular switches and cellular conversations that guide growth, tissue formation, and the emergence of unique body structures, helping us understand both the origins of life and the roots of developmental disorders.
At Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge research accessible to everyone regardless of their scientific background.
Below are the latest studies in developmental biology, offering fresh insights into how life takes shape.
This study presents the first genome-wide analysis of all ten *C. elegans* DMRT genes, revealing that six exhibit sexually dimorphic expression in novel tissues and that their loss causes diverse neuronal differentiation defects, while also highlighting roles for some family members beyond sexual differentiation.
This study reveals that during *Clytia hemisphaerica* embryogenesis, neural cell types arise through two distinct pathways: nematocytes and some ganglionic neurons originate from Piwi/Nanos-expressing interstitial stem cells, while sensory neurons and secretory cells develop via ectodermal delamination during gastrulation.
This longitudinal high-density EEG study of 69 infants reveals that auditory neural maturation during the first year of life follows a non-linear trajectory characterized by increasing response strength and reduced variability, alongside a dynamic shift in phase synchronization that initially improves temporal alignment before decreasing to facilitate more differentiated brain activity.
This study integrates single-cell analysis and machine learning to identify seven ac4C-related prognostic genes in laryngeal squamous cell carcinoma that modulate the tumor immune microenvironment and serve as potential therapeutic targets.
This study employs chromatic persistence, a topological data analysis tool, to characterize the spatial organization and progressive entanglement of ductal, neuronal, and vascular networks during pancreatic development, revealing distinct timelines for loop formation and a concentration of network threading toward the organ's interior.
This study identifies ZNHIT1 as a critical chromatin remodeler that ensures successful male meiosis by facilitating H2A.Z deposition, which cooperates with the transcription factor A-MYB to regulate pachytene gene expression and enable proper homologous recombination.
This paper introduces FuChi, a novel transgenic chicken line equipped with an optimized multicistronic Fucci biosensor that enables precise, real-time tracking of all cell cycle phases in live embryos, thereby revealing critical proliferation dynamics during avian development and establishing a superior in vivo model for studying cell-cycle kinetics.
This study presents a cross-species single-cell transcriptomic atlas of sheep and other eutherian mammals that reveals conserved signaling pathways and species-specific variations in symmetry breaking, establishing sheep as a vital model for understanding human peri-implantation development.
This study demonstrates that while cone photoreceptor ablation in microglia-deficient larval zebrafish triggers a compensatory immune response and only modestly affects Müller glia proliferation and cone regeneration, the presence of these alternative immune cells limits definitive conclusions about microglia's specific role in retinal regeneration.
This study demonstrates that zebrafish can gradually overcome a heritable defect in intestinal protein absorption through recurrent, genome-wide transcriptional changes that hyperactivate endocytic components in specialized enterocytes while simultaneously recalibrating immune responses to ensure survival despite protein malnutrition.